Nomenclature |
CT receptor |
AMY1 receptor |
AMY2 receptor |
AMY3 receptor |
HGNC, UniProt |
CALCR, P30988
|
– |
– |
– |
Subunits |
– |
RAMP1 (Accessory protein), CT receptor |
RAMP2 (Accessory protein), CT receptor |
RAMP3 (Accessory protein), CT receptor |
Principal transduction |
Gs
|
Gs
|
Gs
|
Gs
|
Rank order of potency |
CT (salmon) ≥ CT ≥ AMY, α-CGRP > AM, AM2/IMD |
CT (salmon) ≥ AMY ≥ α-CGRP > AM2/IMD ≥ CT > AM |
Poorly defined |
CT (salmon) ≥ AMY > α-CGRP ≥ AM2/IMD ≥ CT > AM |
Endogenous agonists (pKi) |
CT (Selective) (pEC50 9.0 – 11.2) 486,487,492,498,499,503
|
AMY |
AMY |
AMY |
Radioligands (Kd) |
[125I]CT (salmon) (Agonist, Full agonist) (1x10−10 M), [125I]CT (human) (Agonist, Full agonist) (1x10−10 – 1x10−9 M) |
[125I]BH-AMY (rat, mouse) (Agonist, Full agonist) (1x10−10 – 1x10−9 M) |
[125I]BH-AMY (rat, mouse) (Agonist, Full agonist) (1x10−10 – 1x10−9 M) |
[125I]BH-AMY (rat, mouse) (Agonist, Full agonist) (1x10−10 – 1x10−9 M) |