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. 2013 Dec 17;170(8):1459–1581. doi: 10.1111/bph.12445
Nomenclature CCR6 CCR7 CCR8 CCR9 CCR10
HGNC, UniProt CCR6, P51684 CCR7, P32248 CCR8, P51685 CCR9, P51686 CCR10, P46092
Principal transduction Gi/o Gi/o Gi/o Gi/o Gi/o
Endogenous agonists (pKi) beta-defensin 4A (DEFB4A, DEFB4B, O15263) (Selective) 625, CCL20 (pIC50 7.9 – 8.5) 564,565,606 CCL21 (Selective) (pIC50 9.3) 627, CCL19 (Selective) (pIC50 7.7 – 9.0) 626,627 CCL8 (Mouse), CCL1 (Selective) (pIC50 8.5 – 9.8) 574,585,590 CCL25 (Selective) CCL27 (Selective), CCL28 (Selective)
Selective agonists (pKi) vMIP-I (pIC50 8.9 – 9.9) 574,590
Selective antagonists (pKi) vMCC-I (pIC50 9.4) 574
Radioligands (Kd) [125I]CCL20 (Agonist, Full agonist) (∼1x10-10 M) 582 [125I]CCL19 (Agonist, Full agonist), [125I]CCL21 (Agonist, Full agonist) [125I]CCL1 (human) (Agonist, Full agonist) (2.13x10-10 – 1.2x10-9 M) 590,608 [125I]CCL25 (Agonist, Full agonist)