| Nomenclature | C3a receptor | C5a1 receptor | C5a2 receptor |
| HGNC, UniProt | C3AR1, Q16581 | C5AR1, P21730 | C5AR2, Q9P296 |
| Principal transduction | Gi/o, Gz | Gi/o, Gz, G16 (Buhl et al., 1993) | – |
| Rank order of potency | C3a > C5a 653 | C5a, C5a des-Arg (C5) > C3a 653 | – |
| Endogenous agonists (pKi) | – | RP-S19 (RPS19, P39019) 675 | – |
| Selective agonists (pKi) | E7 (pEC50 8.7) 654 | N-methyl-Phe-Lys-Pro-D-Cha-Cha-D-Arg-CO2H (pIC50 7.6) 664,666 | – |
| Selective antagonists (pKi) | SB290157 (pIC50 7.6) 652 | CHIPS (pKd 9.0) 670, W54011 (8.7) 672, AcPhe-Orn-Pro-D-Cha-Trp-Arg (pIC50 7.9) 674, N-methyl-Phe-Lys-Pro-D-Cha-Trp-D-Arg-CO2H (pIC50 7.2) 666 | – |
| Radioligands (Kd) | [125I]C3a (human) (Agonist, Full agonist) (3.85x10-9 M) 657 | [125I]C5a (human) (Agonist, Full agonist) (2x10-9 M) 661 | [125I]C5a (human) (Agonist, Full agonist) |
| Comment | – | – | Binds C5a complement factor, but appears to lack G protein signalling and has been termed a decoy receptor 671 |
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