Nomenclature |
GAL1 receptor |
GAL2 receptor |
GAL3 receptor |
HGNC, UniProt |
GALR1, P47211
|
GALR2, O43603
|
GALR3, O60755
|
Principal transduction |
Gi/o
|
Gi/o, Gq/11
|
Gi/o
|
Rank order of potency |
galanin > galanin-like peptide 881
|
galanin-like peptide ≥ galanin 881
|
galanin-like peptide > galanin 878
|
Selective agonists (pKi) |
– |
[D-Trp2]galanin-(1–29) (8.15 - Rat) 887, galanin(2–29) (rat/mouse) (7.25–8.72 - Rat) 882,891–893
|
– |
Selective antagonists (pKi) |
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide (pIC50 5.57) 884
|
M871 (7.88) 889
|
– |