| Nomenclature | HCA1 receptor | HCA2 receptor | HCA3 receptor |
| HGNC, UniProt | HCAR1, Q9BXC0 | HCAR2, Q8TDS4 | HCAR3, P49019 |
| Principal transduction | Gi/o 1031,1034,1036. | Gi/o 1040,1044,1045 | Gi/o 1040,1045 |
| Endogenous agonists (pKi) | L-lactic acid (Selective) (pEC50 1.3 – 2.89) 1032,1034,1036,1041 | β-D-hydroxybutyric acid (pEC50 3.1) 1042 | 3-hydroxyoctanoic acid (pEC50 5.1) 1031 |
| Selective agonists (pKi) | 3,5-dihydroxybenzoic acid (pEC50 3.72) 1035 | MK 6892 (pEC50 7.8) 1039, MK 1903 (pEC50 7.56) 1033, nicotinic acid (pEC50 6.0 – 7.2) 1040,1044,1045, acipimox (pEC50 5.2 – 5.6) 1040,1045, monomethylfumarate (pEC50 5.03) 1043 | 1-isopropylbenzotriazole-5-carboxylic acid (pEC50 6.4) 1038 |
| Radioligands (Kd) | – | [3H]nicotinic acid (Agonist, Full agonist) (5.01x10-8 – 1x10-7 M) 1040,1044,1045 | – |
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