Nomenclature	mGlu1 receptor	mGlu5 receptor
HGNC, UniProt	GRM1, Q13255	GRM5, P41594
Principal transduction	Gq/11	Gq/11
Selective agonists (pKi)	–	(S)-(+)-CBPG (Partial agonist) (pEC50 4.3 - Rat) 1225, CHPG (pIC50 3.4) 1232
Selective antagonists (pKi)	AIDA (pA2 4.2) 1231, 3-MATIDA (pIC50 5.2-Rat) 1230, LY367385 (pIC50 5.1) 1196, (S)-(+)-CBPG (pIC50 4.2-Rat) 1225, (S)-TBPG (pIC50 4.2-Rat) 1197	ACDPP (pIC50 6.9) 1188
Selective allosteric regulators	PHCCC (Positive), Ro67-7476 (Positive) (pKi 7.5–7.9 - Rat) 1213, Ro01-6128 (Positive) (pKi 7.5–7.7 - Rat) 1213, Ro67-4853 (Positive) (pKi 5.1 - Rat) 1213, JNJ16259685 (Negative) (pIC50 8.9) 1217, A-841720 (Negative) (pIC50 8.0) 1255, 3,5-dimethyl PPP (Negative) (pIC50 7.8-Rat) 1227, YM298198 (Negative) (pIC50 7.8-Rat) 1214, BAY 367620 (Negative) (pIC50 6.8–8.0-Rat) 1193,1216, EM-TBPC (Negative) (pIC50 6.9-Rat) 1223, LY456236 (Negative) (pIC50 6.9) 1218, CPCCOEt (Negative) (pIC50 5.2–5.8) 1220	MTEP (Negative) (pKi 7.8) 1191, VU-1545 (Positive) (pEC50 8.0) 1198, CDPPB (Positive) (pEC50 7.6–8.0) 1211,1219, MPEP (Negative) (pIC50 7.4–7.7) 1202,1204, fenobam (Negative) (pIC50 7.2) 1241, DFB (Positive) (pIC50 5.6–8.5) 1236,1237, CPPHA (Positive) (pIC50 6.3) 1237, SIB-1757 (Negative) (pIC50 6.0–6.4) 1202,1252, SIB-1893 (Negative) (pIC50 5.9–6.5) 1202,1252