| Nomenclature | NPFF1 receptor | NPFF2 receptor |
| HGNC, UniProt | NPFFR1, Q9GZQ6 | NPFFR2, Q9Y5X5 |
| Principal transduction | Gq/11 | Gi/o 1293 |
| Rank order of potency | FMRF, NPFF > NPAF > NPSF, QRFP, PrRP-31 (PRLH) 1287 | NPAF, NPFF > PrRP-31 (PRLH) > FMRF, QRFP (QRFP, P83859) > NPSF 1287 |
| Endogenous agonists (pKi) | RFRP-3 (NPVF, Q9HCQ7) (Selective) (9.2 – 9.3) 1288,1289,1292, NPFF (NPFF, O15130) (Selective) (8.5 – 9.9) 1287,1288,1292 | NPFF (Selective) (9.7) 1288,1291 |
| Selective agonists (pKi) | – | dNPA (10.6) 1294,1295, AC263093 (pEC50 5.2 – 5.9) 1290 |
| Selective antagonists (pKi) | AC262620 (7.7 – 8.1) 1290, AC262970 (7.4 – 8.1) 1290, RF9 (7.2) 1296 | – |
| Radioligands (Kd) | [125I]NPFF (Agonist, Full agonist) 1287, [125I]Y-RFRP-3 (Agonist, Full agonist) (8x10-9 M) 1288, [3H]NPVF (Agonist, Full agonist) (2.65x10-9 M) 1297 | [125I]NPFF (Agonist, Full agonist) 1287, [125I]EYF (Agonist, Full agonist) (6.3x10-11 M) 1292, [3H]EYF (Agonist, Full agonist) (5.4x10-10 M) 1297 |
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