| Nomenclature | VPAC1 receptor | VPAC2 receptor | PAC1 receptor |
| HGNC, UniProt | VIPR1, P32241 | VIPR2, P41587 | ADCYAP1R1, P41586 |
| Principal transduction | Gs | Gs | Gs |
| Rank order of potency | VIP, PACAP-27, PACAP-38 >> GHRH (GHRH, P01286), PHI, secretin (SCT, P09683) | VIP, PACAP-38, PACAP-27 > PHI >> GHRH (GHRH, P01286), secretin (SCT, P09683) | PACAP-27, PACAP-38 >> VIP |
| Selective agonists (pKi) | [Ala11,22,28]VIP (8.1) 1755, [Lys15,Arg16,Leu27]VIP-(1–7)/GRF-(8–27)-NH2 (pEC50 8.3) 1751 | Ro 25-1392 (8.0) 1760, Ro 25-1553 (pEC50 8.7) 1751, Ro 25-1553 (pEC50 8.3) 1750, Ro 25-1553 (pIC50 9.5) 1748, Ro 25-1553 (pIC50 8.8) 1750, Ro 25-1553 (pIC50 7.8) 1751 | maxadilan (pEC50 10.3) 1746, maxadilan (pEC50 6.2) 1746 |
| Selective antagonists (pKi) | PG 97-269 (pIC50 8.7) 1747, PG 97-269 (pIC50 8.7) 1750, PG 97-269 (pIC50 8.7) 1750, PG 97-269 (pIC50 8.0) 1746, PG 97-269 (pIC50 7.1) 1746 | – | – |
| Radioligands (Kd) | [125I]PACAP-27 (Agonist), [125I]VIP (Agonist) (4x10-10 M) 1755 | [125I]PACAP-27 (Agonist), [125I]VIP (Agonist) (7x10-10 M) 1755 | [125I]PACAP-27 (Agonist) (8.7x10-10 M) 1756 |
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