Nomenclature	GluK1	GluK2	GluK3	GluK4	GluK5
HGNC, UniProt	GRIK1, P39086	GRIK2, Q13002	GRIK3, Q13003	GRIK4, Q16099	GRIK5, Q16478
Agonists (EC50)	8-deoxy-neodysiherbaine (Full agonist), ATPA (Full agonist), domoic acid (Full agonist), dysiherbaine (Full agonist), (S)-4-AHCP (Full agonist), (S)-5-iodowillardiine, kainate (Full agonist), LY339434 (Full agonist), SYM2081 (Full agonist)	domoic acid (Full agonist), dysiherbaine (Full agonist), kainate (Full agonist), SYM2081 (Full agonist)	dysiherbaine (Full agonist), kainate (Full agonist, low potency), SYM2081 (Full agonist)	domoic acid (Full agonist), dysiherbaine (Full agonist), kainate (Full agonist), SYM2081 (Full agonist)	domoic acid (Full agonist), dysiherbaine (Full agonist), kainate (Full agonist), SYM2081 (Full agonist)
Selective antagonists (IC50)	2,4-epi-neodysiherbaine, ACET, LY382884, LY466195, MSVIII-19, NS3763 (non-competitive), UBP302, UBP310	2,4-epi-neodysiherbaine	–	–	–
Allosteric Regulators	concanavalin A (Positive)	concanavalin A (Positive)	–	–	–
Radioligands (Kd)	[3H](2S,4R)-4-methylglutamate, [3H]kainate, [3H]UBP310 (2.1x10-8 M) 138	[3H](2S,4R)-4-methylglutamate, [3H]kainate	[3H](2S,4R)-4-methylglutamate, [3H]kainate, [3H]UBP310 (5.6x10-7 M) 138	[3H](2S,4R)-4-methylglutamate, [3H]kainate	[3H](2S,4R)-4-methylglutamate, [3H]kainate
Comment	–	Intracellular polyamines are subtype selective channel blockers (GluK3 >> GluK2)	domoic acid and concanavalin A are inactive at the GluK3 subunit. Intracellular polyamines are subtype selective channel blockers (GluK3 >> GluK2)	–	–