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. 2013 Dec 17;170(8):1582–1606. doi: 10.1111/bph.12446
Nomenclature α8 (avian)* α9*
HGNC, UniProt CHRNA9, Q9UGM1
Commonly used antagonists (α8)5: α-bungarotoxin > atropine ≥ (+)-tubocurarine ≥ strychnine (α9)5: α-bungarotoxin > methyllycaconitine > strychnine ∼ tropisetron > (+)-tubocurarine; α9α10: α-bungarotoxin > tropisetron = strychnine > (+)-tubocurarine
Selective antagonists (IC50) α-bungarotoxin (α9α10), α-bungarotoxin ((α9)5), α-conotoxin RgIA (α9α10), muscarine (α9α10), muscarine ((α9)5), nicotine (α9α10), nicotine ((α9)5), strychnine (α9α10), strychnine ((α9)5)
Radioligands (Kd) [3H]epibatidine ((α8)5) (2x10-10 M), [125I]α-bungarotoxin (native α8*) (5.5x10-9 M), [3H]α-bungarotoxin (native α8*) (5.5x10-9 M) [125I]α-bungarotoxin, [3H]α-bungarotoxin, [3H]methyllycaconitine (α9α10) (7.5x10-9 M)
Functional characteristics (α9)5: PCa/PNa = 9; α9α10: PCa/PNa = 9, Pf = 22%