Nomenclature |
α8 (avian)* |
α9* |
HGNC, UniProt |
– |
CHRNA9, Q9UGM1
|
Commonly used antagonists |
(α8)5: α-bungarotoxin > atropine ≥ (+)-tubocurarine ≥ strychnine |
(α9)5: α-bungarotoxin > methyllycaconitine > strychnine ∼ tropisetron > (+)-tubocurarine; α9α10: α-bungarotoxin > tropisetron = strychnine > (+)-tubocurarine |
Selective antagonists (IC50) |
– |
α-bungarotoxin (α9α10), α-bungarotoxin ((α9)5), α-conotoxin RgIA (α9α10), muscarine (α9α10), muscarine ((α9)5), nicotine (α9α10), nicotine ((α9)5), strychnine (α9α10), strychnine ((α9)5) |
Radioligands (Kd) |
[3H]epibatidine ((α8)5) (2x10-10 M), [125I]α-bungarotoxin (native α8*) (5.5x10-9 M), [3H]α-bungarotoxin (native α8*) (5.5x10-9 M) |
[125I]α-bungarotoxin, [3H]α-bungarotoxin, [3H]methyllycaconitine (α9α10) (7.5x10-9 M) |
Functional characteristics |
– |
(α9)5: PCa/PNa = 9; α9α10: PCa/PNa = 9, Pf = 22% |