Nomenclature	HGNC, UniProt	Other chemical activators	Physical activators	Endogenous activators (EC50)	Activators (EC50)	Endogenous channel blockers (IC50)	Channel Blockers (IC50)	Functional characteristics
TRPM2	TRPM2, O94759	agents producing reactive oxygen (e.g. H2O2) and nitrogen (e.g. GEA 3162) species	heat ∼ 35°C	intracellular ADP ribose, arachidonic acid (Potentiation), intracellular cADPR, intracellular Ca2+ (via calmodulin), H2O2	GEA 3162	extracellular H+, Zn2+ (1x10-6 M)	2-APB, ACAA, clotrimazole, econazole, flufenamic acid, miconazole	γ = 52-60 pS at negative potentials, 76 pS at positive potentials; conducts mono- and di-valent cations non-selectively (PCa/PNa = 0.6–0.7); non-rectifying; inactivation at negative potentials; activated by oxidative stress probably via PARP-1, PARP inhibitors reduce activation by oxidative stress, activation inhibited by suppression of APDR formation by glycohydrolase inhibitors