Nomenclature	HGNC, UniProt	Other chemical activators	Physical activators	Activators (EC50)	Channel Blockers (IC50)	Functional characteristics	Comment
TRPM8	TRPM8, Q7Z2W7	agonist activities are temperature dependent and potentiated by cooling	depolarization (V½ ∼ +50 mV at 15°C), cooling (< 22–26°C)	icilin (requires intracellular Ca2+ as a co-factor for full agonist activity), (-)-menthol (inhibited by intracellular Ca2+), WS-12	2-APB, 5-benzyloxytryptamine, ACAA, AMTB 286, anandamide, BCTC, cannabidiol, capsazepine, clotrimazole, Δ9-tetrahydrocannabinol, La3+, linoleic acid, NADA	γ = 40-83 pS at positive potentials; conducts mono- and di-valent cations non-selectively (PCa/PNa = 1.0–3.3); pronounced outward rectification; demonstrates densensitization to chemical agonists and adaptation to a cold stimulus in the presence of Ca2+; modulated by lysophospholipids and PUFAs	cannabidiol and Δ9-tetrahydrocannabinol are examples of cannabinoids. TRPM8 is insensitive to ruthenium red