Nomenclature	TRPV5	TRPV6
HGNC, UniProt	TRPV5, Q9NQA5	TRPV6, Q9H1D0
Activators	constitutively active (with strong buffering of intracellular Ca2+)	constitutively active (with strong buffering of intracellular Ca2+)
Activators (EC50)	–	2-APB (Potentiation)
Other channel blockers	Pb2+ = Cu2+ = Gd3+ > Cd2+ > Zn2+ > La3+ > Co2+ > Fe2+	–
Channel Blockers (IC50)	econazole, Mg2+, miconazole, ruthenium red (1.21x10-7 M)	Cd2+, La3+, Mg2+, ruthenium red (9x10-6 M)
Functional characteristics	γ = 59–78 pS for monovalent ions at negative potentials, conducts mono- and di-valents with high selectivity for divalents (PCa/PNa > 107); voltage- and time- dependent inward rectification; inhibited by intracellular Ca2+ promoting fast inactivation and slow downregulation; feedback inhibition by Ca2+ reduced by calcium binding protein 80-K-H; inhibited by extracellular and intracellular acidosis; upregulated by 1,25-dihydrovitamin D3	γ = 58–79 pS for monovalent ions at negative potentials, conducts mono- and di-valents with high selectivity for divalents (PCa/PNa > 130); voltage- and time-dependent inward rectification; inhibited by intracellular Ca2+ promoting fast and slow inactivation; gated by voltage-dependent channel blockade by intracellular Mg2+; slow inactivation due to Ca2+-dependent calmodulin binding; phosphorylation by PKC inhibits Ca2+-calmodulin binding and slow inactivation; upregulated by 1,25-dihydroxyvitamin D3