| Nomenclature | TRPP2 | TRPP3 |
| HGNC, UniProt | PKD2L1, Q9P0L9 | PKD2L2, Q9NZM6 |
| Activators | Low constitutive activity, enhanced by membrane depolarization; changes in cell volume affect voltage-dependent gating (increased channel opening probability with cell swelling) | – |
| Channel Blockers (IC50) | flufenamate, Gd3+, La3+, phenamil (1.4x10-7 M), benzamil (1.1x10-6 M), EIPA (1.05x10-5 M), amiloride (1.43x10-4 M) | – |
| Functional characteristics | γ = 105–137 pS (outward conductance) 184–399 pS (inward conductance), conducts mono- and di-valent cations with a preference for divalents (PCa/PNa = 4.0–4.3); steady state currents rectify outwardly, whereas instantaneous currents show strong inward rectification; activated and subsequently inactivated by intracellular Ca2+ (human, but not mouse); inhibited by extracellular acidification and potentiated by extracellular alkalization | – |
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