| Nomenclature | Activators (EC50) | Endogenous channel blockers (IC50) | Channel Blockers (IC50) | Functional characteristics | Comment |
| Maxi Cl- | extracellular chlorpromazine, cytosolic GTPγS, extracellular tamoxifen, extracellular toremifene, extracellular triflupromazine | intracellular arachidonic acid | DPC, extracellular Gd3+, SITS, DIDS (4x10-5 M) 149, extracellular Zn2+ (5x10-5 M) 131, NPPB (1.56x10-4 M) 149 | γ = 280–430 pS (main state); permeability sequence, I > Br > Cl > F > gluconate (PCIPCl = ∼1.5); ATP is a voltage dependent permeant blocker of single channel activity (PATP/PCl = 0.08–0.1); channel activity increased by patch-excision; channel opening probability (at steady-state) maximal within approximately ± 20 mV of 0 mV, opening probability decreased at more negative and (commonly) positive potentials yielding a bell-shaped curve; channel conductance and opening probability regulated by annexin 6 | Maxi Cl- is also activated by G protein-coupled receptors and cell swelling. tamoxifen and toremifene are examples of triphenylethylene anti-oestrogens |
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