Nomenclature |
K2P1.1, K2P6.1, K2P7.1 |
K2P2.1, K2P10.1, K2P4.1 |
K2P3.1, K2P9.1, K2P15.1 |
K2P16.1, K2P5.1, K2P17.1 |
K2P13.1, K2P12.1 |
K2P18.1 |
HGNC, UniProt |
KCNK1, O00180; KCNK6, Q9Y257; KCNK7, Q9Y2U2
|
KCNK2, O95069; KCNK10, P57789; KCNK4, Q9NYG8
|
KCNK3, O14649; KCNK9, Q9NPC2; KCNK15, Q9H427
|
KCNK16, Q96T55; KCNK5, O95279; KCNK17, Q96T54
|
KCNK13, Q9HB14; KCNK12, Q9HB15
|
KCNK18, Q7Z418
|
Endogenous activators (EC50) |
– |
arachidonic acid |
– |
– |
– |
– |
Activators (EC50) |
– |
halothane, riluzole |
halothane |
– |
– |
– |
Inhibitors |
– |
– |
anandamide, ruthenium red |
– |
halothane |
– |
Endogenous inhibitors |
– |
– |
– |
– |
– |
arachidonic acid |
Functional characteristics |
Background current |
Background current |
Background current |
Background current |
Background current |
Background current |
Comment |
K2P1.1 is inhibited by acid pHi, K2P6.1 is inhibited by acid pHi, K2P7.1 is inhibited by acid pHi
|
K2P2.1 is also activated by stretch, heat and acid pHi, K2P10.1 is also activated by stretch, heat and acid pHi, K2P4.1 is also activated by stretch, heat and acid pHi
|
K2P3.1 is also activated by alkakine pHo and inhibited by acid pHo, K2P9.1 is also inhibited by acid pHo, K2P15.1 is inhibited by acid pHo
|
K2P16.1 is activated by alkaline pHo, K2P5.1 is activated by alkaline pHo, K2P17.1 is activated by alkaline pHo
|
– |
– |