| Nomenclature | HGNC, UniProt | Activators | Channel Blockers (IC50) | Functional characteristics |
| Navi2.1 | NALCN, Q8IZF0 | Constitutively active (Lu et al., 2007), or activated downstream of Src family tyrosine kinases (SFKs) (Lu et al., 2009; Swayne et al., 2009); positively modulated by decreased extracellular Ca2+ concentration (Lu et al., 2010) 222–224,226 | Gd3+ (1.4x10-6 M), Cd2+ (1.5x10-4 M), Co2+ (2.6x10-4 M), verapamil (3.8x10-4 M) | γ = 27 pS (by fluctuation analysis), PNa/PCs = 1.3, PK/PCs = 1.2, PCa/PCs = 0.5, linear current voltage-relationship, voltage-independent and non-inactivating |
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