Skip to main content
. 2013 Dec 17;170(8):1706–1796. doi: 10.1111/bph.12450
Nomenclature Sodium-dependent vitamin C transporter 1 Sodium-dependent vitamin C transporter 2 Sodium-dependent vitamin C transporter 3 Sodium-dependent nucleobase transporter
Systematic nomenclature SLC23A1 SLC23A2 SLC23A3 SLC23A4
Common abbreviation SVCT1 SVCT2 SVCT3 SNBT1
HGNC, UniProt SLC23A1, Q9UHI7 SLC23A2, Q9UGH3 SLC23A3, Q6PIS1 SLC23A4P, –
Endogenous substrates L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid 308 L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid 308 uracil > thymine > guanine, hypoxanthine > xanthine, uridine 309
Substrates
Inhibitors (pIC50) phloretin 308 5-fluorouracil 309
Radioligands (Kd) [14C]ascorbic acid [14C]ascorbic acid
Stoichiometry 2 Na+: 1 ascorbic acid (in) 308 2 Na+: 1 ascorbic acid (in) 308 1 Na+: 1 uracil (in) 309
Comment SLC23A3 does not transport ascorbic acid and remains an orphan transporter. SLC23A4/SNBT1 is found in rodents and non-human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P