Nomenclature |
Sodium-dependent vitamin C transporter 1 |
Sodium-dependent vitamin C transporter 2 |
Sodium-dependent vitamin C transporter 3 |
Sodium-dependent nucleobase transporter |
Systematic nomenclature |
SLC23A1 |
SLC23A2 |
SLC23A3 |
SLC23A4 |
Common abbreviation |
SVCT1 |
SVCT2 |
SVCT3 |
SNBT1 |
HGNC, UniProt |
SLC23A1, Q9UHI7
|
SLC23A2, Q9UGH3
|
SLC23A3, Q6PIS1
|
SLC23A4P, – |
Endogenous substrates |
L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid 308
|
L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid 308
|
– |
uracil > thymine > guanine, hypoxanthine > xanthine, uridine 309
|
Substrates |
– |
– |
– |
– |
Inhibitors (pIC50) |
phloretin 308
|
– |
– |
5-fluorouracil 309
|
Radioligands (Kd) |
[14C]ascorbic acid |
[14C]ascorbic acid |
– |
– |
Stoichiometry |
2 Na+: 1 ascorbic acid (in) 308
|
2 Na+: 1 ascorbic acid (in) 308
|
– |
1 Na+: 1 uracil (in) 309
|
Comment |
– |
– |
SLC23A3 does not transport ascorbic acid and remains an orphan transporter. |
SLC23A4/SNBT1 is found in rodents and non-human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P |