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. 2013 Dec 17;170(8):1706–1796. doi: 10.1111/bph.12450
Nomenclature Alanine/serine/cysteine transporter 1 Alanine/serine/cysteine transporter 2
Systematic nomenclature SLC1A4 SLC1A5
Common abbreviation ASCT1 ASCT2
HGNC, UniProt SLC1A4, P43007 SLC1A5, Q15758
Endogenous substrates L-cysteine > L-alanine = L-serine > L-threonine L-alanine = L-serine = L-cysteine (low Vmax) = L-threonine = L-glutamine = L-asparagine >> L-methionine ≅ glycine ≅ L-leucine > L-valine > L-glutamic acid (enhanced at low pH)
Inhibitors (pIC50) benzylcysteine 58, benzylserine 58, p-nitrophenyl glutamyl anilide 49
Stoichiometry 1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; 95) 1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; 39)