Nomenclature |
Alanine/serine/cysteine transporter 1 |
Alanine/serine/cysteine transporter 2 |
Systematic nomenclature |
SLC1A4 |
SLC1A5 |
Common abbreviation |
ASCT1 |
ASCT2 |
HGNC, UniProt |
SLC1A4, P43007
|
SLC1A5, Q15758
|
Endogenous substrates |
L-cysteine > L-alanine = L-serine > L-threonine |
L-alanine = L-serine = L-cysteine (low Vmax) = L-threonine = L-glutamine = L-asparagine >> L-methionine ≅ glycine ≅ L-leucine > L-valine > L-glutamic acid (enhanced at low pH) |
Inhibitors (pIC50) |
– |
benzylcysteine 58, benzylserine 58, p-nitrophenyl glutamyl anilide 49
|
Stoichiometry |
1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; 95) |
1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; 39) |