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. 2013 Dec 17;170(8):1706–1796. doi: 10.1111/bph.12450
Systematic nomenclature Common abbreviation HGNC, UniProt Comment
ABCB1 MDR1, PGP1 ABCB1, P08183 Responsible for the cellular export of many therapeutic drugs. The mouse and rat have two Mdr1 genes (gene names; Mdr1a and Mdr1b) while the human has only the one gene, MDR1
ABCB2 TAP1 TAP1, Q03518 Endoplasmic reticulum peptide transporter, possibly requires heterodimerization with TAP2
ABCB3 TAP2 TAP2, Q03519 Endoplasmic reticulum peptide transporter, possibly requires heterodimerization with TAP1
ABCB4 PGY3 ABCB4, P21439 Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane 13
ABCB5 ABCB5, Q2M3G0 Multidrug resistance protein in, and marker of, melanoma cells 17
ABCB6 MTABC3 ABCB6, Q9NP58 Putative mitochondrial porphyrin transporter 11; other subcellular localizations are possible, such as the plasma membrane, as a specific determinant of the Langereis blood group system 5
ABCB7 ABC7 ABCB7, O75027 Mitochondrial; reportedly essential for haematopoiesis 15
ABCB8 MABC1 ABCB8, Q9NUT2 Mitochondrial; suggested to play a role in chemoresistance of melanoma 4
ABCB9 TAPL ABCB9, Q9NP78 Reported to be lysosomal 7
ABCB10 MTABC2 ABCB10, Q9NRK6 Mitochondrial location; the first human ABC transporter to have a crystal structure reported 18
ABCB11 ABC16 ABCB11, O95342 Loss-of-function mutations are associated with progressive familial intrahepatic cholestasis type 2 19