Systematic nomenclature |
Common abbreviation |
HGNC, UniProt |
Comment |
ABCB1 |
MDR1, PGP1 |
ABCB1, P08183
|
Responsible for the cellular export of many therapeutic drugs. The mouse and rat have two Mdr1 genes (gene names; Mdr1a and Mdr1b) while the human has only the one gene, MDR1 |
ABCB2 |
TAP1 |
TAP1, Q03518
|
Endoplasmic reticulum peptide transporter, possibly requires heterodimerization with TAP2 |
ABCB3 |
TAP2 |
TAP2, Q03519
|
Endoplasmic reticulum peptide transporter, possibly requires heterodimerization with TAP1 |
ABCB4 |
PGY3 |
ABCB4, P21439
|
Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane 13
|
ABCB5 |
– |
ABCB5, Q2M3G0
|
Multidrug resistance protein in, and marker of, melanoma cells 17
|
ABCB6 |
MTABC3 |
ABCB6, Q9NP58
|
Putative mitochondrial porphyrin transporter 11; other subcellular localizations are possible, such as the plasma membrane, as a specific determinant of the Langereis blood group system 5
|
ABCB7 |
ABC7 |
ABCB7, O75027
|
Mitochondrial; reportedly essential for haematopoiesis 15
|
ABCB8 |
MABC1 |
ABCB8, Q9NUT2
|
Mitochondrial; suggested to play a role in chemoresistance of melanoma 4
|
ABCB9 |
TAPL |
ABCB9, Q9NP78
|
Reported to be lysosomal 7
|
ABCB10 |
MTABC2 |
ABCB10, Q9NRK6
|
Mitochondrial location; the first human ABC transporter to have a crystal structure reported 18
|
ABCB11 |
ABC16 |
ABCB11, O95342
|
Loss-of-function mutations are associated with progressive familial intrahepatic cholestasis type 2 19
|