Nomenclature | B0AT1 | B0AT2 | B0AT3 | NTT5 | NTT4 | SIT1 |
Systematic nomenclature | SLC6A19 | SLC6A15 | SLC6A18 | SLC6A16 | SLC6A17 | SLC6A20 |
HGNC, UniProt | SLC6A19, Q695T7 | SLC6A15, Q9H2J7 | SLC6A18, Q96N87 | SLC6A16, Q9GZN6 | SLC6A17, Q9H1V8 | SLC6A20, Q9NP91 |
Endogenous substrates | L-leucine, L-methionine, L-isoleucine, L-valine > L-asparagine, L-phenylalanine, L-alanine, L-serine > L-threonine, glycine, L-proline 152 | L-proline > L-alanine, L-valine, L-methionine, L-leucine > L-isoleucine, L-threonine, L-asparagine, L-serine, L-phenylalanine > glycine 152 | L-alanine, glycine > L-methionine, L-phenylalanine, L-leucine, L-histidine, L-glutamine 203 | – | L-leucine, L-methionine, L-proline > L-cysteine, L-alanine, L-glutamine, L-serine > L-histidine, glycine 209 | L-proline |
Stoichiometry | 1 Na+: 1 amino acid 154 | 1 Na+: 1 amino acid 151 | Na+- and Cl- -dependent transport 193 | – | Na+-dependent, Cl--independent transport 209 | 2 Na+: 1 Cl-: 1 imino acid 150 |
Comment | Mutations in B0AT1 are associated with Hartnup disorder | – | – | – | – | – |