Nomenclature | Cystathionine β-synthase | Cystathionine γ-lyase | L-Cysteine:2-oxoglutarate aminotransferase | 3-Mercaptopyruvate sulfurtransferase |
Common abbreviation | CBS | CSE | CAT | MPST |
HGNC, UniProt | CBS, P35520 | CTH, P32929 | CCBL1, Q16773 | MPST, P25325 |
EC number | 4.2.1.22 | 4.4.1.1 | 4.4.1.13 | 2.8.1.2 |
Endogenous substrates | L-homocysteine, L-cysteine (Km 6x10-3 M) 269 | L-cysteine | L-cysteine | 3-mercaptopyruvic acid (Km 1.2x10-3 M) 270 |
Products | cystathionine | NH3, pyruvic acid | NH3, pyruvic acid | pyruvic acid |
Cofactors | pyridoxal phosphate | pyridoxal phosphate | pyridoxal phosphate | Zn2+ |
Inhibitors (pIC50) | aminooxyacetic acid | propargylglycine | – | – |