Nomenclature | Caspase 9 | Caspase 10 | Caspase 14 |
HGNC, UniProt | CASP9, P55211 | CASP10, Q92851 | CASP14, P31944 |
EC number | 3.4.22.62 | 3.4.22.63 | 3.4.22.- |
Endogenous activators | – | DISC | – |
Endogenous substrates | caspase 9, PARP, pro-caspase 3, pro-caspase 6, pro-caspase 7 | caspase 10, pro-caspase 3, pro-caspase 6, pro-caspase 7 | – |
Selective inhibitors (pIC50) | Z-LEHD-FMK 298 | – | – |
Comment | Consists of caspase-9 subunit p35 and caspase-9 subunit p10 (see Uniprot entry) | Consists of caspase-10 subunit p23/17 and caspase-10 subunit p12 (see Uniprot entry) | Consists of caspase-14 subunit p19 and caspase-14 subunit p10 (see Uniprot entry) |