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. 2013 Dec 17;170(8):1797–1867. doi: 10.1111/bph.12451
Nomenclature thyroid peroxidase
Common abbreviation TPO
HGNC, UniProt TPO, P07202
EC number 1.11.1.8: [Thyroglobulin]-L-tyrosine + I- + H2O2 + H+ -> [Thyroglobulin]-3,5,3′-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Cofactors Ca2+
Selective inhibitors (pIC50) methimazole 363, propylthiouracil 363
Comment Carbimazole is a pro-drug for methimazole