Nomenclature | thyroid peroxidase |
Common abbreviation | TPO |
HGNC, UniProt | TPO, P07202 |
EC number | 1.11.1.8: [Thyroglobulin]-L-tyrosine + I- + H2O2 + H+ -> [Thyroglobulin]-3,5,3′-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O |
Cofactors | Ca2+ |
Selective inhibitors (pIC50) | methimazole 363, propylthiouracil 363 |
Comment | Carbimazole is a pro-drug for methimazole |