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. 2013 Dec 17;170(8):1797–1867. doi: 10.1111/bph.12451
Nomenclature Histidine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Phosphatidylserine decarboxylase
Common abbreviation HDC MLYCD ODC PSDC
HGNC, UniProt HDC, P19113 MLYCD, O95822 ODC1, P11926 PISD, Q9UG56
EC number 4.1.1.22 4.1.1.9 4.1.1.17 4.1.1.65
Endogenous substrates L-histidine malonyl-CoA L-ornithine phosphatidylserine
Products histamine acetyl CoA putrescine phosphatidylethanolamine
Cofactors pyridoxal phosphate pyridoxal phosphate pyridoxal phosphate pyruvic acid
Selective inhibitors (pIC50) AMA, FMH 37 APA, DFMO
Comment Inhibited by AMP-activated protein kinase-evoked phosphorylation 40 The activity of ODC is regulated by the presence of an antizyme (ENSG00000104904) and an ODC antizyme inhibitor (ENSG00000155096) S-allylglycine is also an inhibitor of SAMDC 39