Nomenclature | Histidine decarboxylase | Malonyl-CoA decarboxylase | Ornithine decarboxylase | Phosphatidylserine decarboxylase |
Common abbreviation | HDC | MLYCD | ODC | PSDC |
HGNC, UniProt | HDC, P19113 | MLYCD, O95822 | ODC1, P11926 | PISD, Q9UG56 |
EC number | 4.1.1.22 | 4.1.1.9 | 4.1.1.17 | 4.1.1.65 |
Endogenous substrates | L-histidine | malonyl-CoA | L-ornithine | phosphatidylserine |
Products | histamine | acetyl CoA | putrescine | phosphatidylethanolamine |
Cofactors | pyridoxal phosphate | pyridoxal phosphate | pyridoxal phosphate | pyruvic acid |
Selective inhibitors (pIC50) | AMA, FMH 37 | – | APA, DFMO | – |
Comment | – | Inhibited by AMP-activated protein kinase-evoked phosphorylation 40 | The activity of ODC is regulated by the presence of an antizyme (ENSG00000104904) and an ODC antizyme inhibitor (ENSG00000155096) | S-allylglycine is also an inhibitor of SAMDC 39 |