Nomenclature |
Adenosine deaminase |
Adenosine kinase |
Ecto-5′-Nucleotidase |
S-Adenosylhomocysteine hydrolase |
Common abbreviation |
ADA |
ADK |
NT5E |
SAHH |
HGNC, UniProt |
ADA, P00813
|
ADK, P55263
|
NT5E, P21589
|
AHCY, P23526
|
EC number |
3.5.4.4 |
2.7.1.20 |
3.1.3.5 |
3.3.1.1 |
Rank order of affinity |
2'-deoxyadenosine > adenosine |
adenosine |
AMP, 5′-GMP, 5′-IMP, 5′-UMP > 5′-dAMP, 5′-dGMP |
S-adenosylhomocysteine |
Products |
2'-deoxyinosine, inosine |
AMP |
adenosine, guanine, inosine, uridine |
adenosine |
Selective inhibitors (pIC50) |
EHNA (pKi 8.8) 8, pentostatin (10.8) 8
|
A134974 (10.2) 14, ABT702 (8.8) 11
|
αβ-methyleneADP (8.7) 9
|
3-deazaadenosine (8.5) 10
|