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. 2013 Dec 17;170(8):1797–1867. doi: 10.1111/bph.12451
Nomenclature Adenosine deaminase Adenosine kinase Ecto-5′-Nucleotidase S-Adenosylhomocysteine hydrolase
Common abbreviation ADA ADK NT5E SAHH
HGNC, UniProt ADA, P00813 ADK, P55263 NT5E, P21589 AHCY, P23526
EC number 3.5.4.4 2.7.1.20 3.1.3.5 3.3.1.1
Rank order of affinity 2'-deoxyadenosine > adenosine adenosine AMP, 5′-GMP, 5′-IMP, 5′-UMP > 5′-dAMP, 5′-dGMP S-adenosylhomocysteine
Products 2'-deoxyinosine, inosine AMP adenosine, guanine, inosine, uridine adenosine
Selective inhibitors (pIC50) EHNA (pKi 8.8) 8, pentostatin (10.8) 8 A134974 (10.2) 14, ABT702 (8.8) 11 αβ-methyleneADP (8.7) 9 3-deazaadenosine (8.5) 10