| Nomenclature | Common name | HGNC, UniProt | EC number | Comment |
| CYP11A1 | – | CYP11A1, P05108 | 1.14.15.6 | Converts cholesterol to pregnenolone plus 4-methylpentanal |
| CYP11B1 | – | CYP11B1, P15538 | 1.14.15.4 | Converts deoxycortisone and 11-deoxycortisol to cortisone and cortisol, respectively Loss-of-function mutations are associated with familial adrenal hyperplasia and hypertension Inhibited by metyrapone 166 |
| CYP11B2 | Aldosterone synthase | CYP11B2, P19099 | 1.14.15.4, 1.14.15.5 | Converts corticosterone to aldosterone |
| CYP17A1 | – | CYP17A1, P05093 | 1.14.99.9 | Converts pregnenolone and progesterone to 17α-hydroxypregnenolone and 17α-hydroxyprogesterone, respectively. Converts 17α-hydroxypregnenolone and 17α-hydroxyprogesterone to dehydroepiandrosterone and androstenedione, respectively Converts corticosterone to cortisol. Inhibited by abiraterone (pIC50 8.4) 160 |
| CYP19A1 | Aromatase | CYP19A1, P11511 | 1.14.14.1 | Converts androstenedione and testosterone to estrone and 17β-estradiol, respectively Inhibited by anastrazole 159, and letrozole 144 |
| CYP20A1 | – | CYP20A1, Q6UW02 | 1.14.-.- | – |
| CYP21A2 | – | CYP21A2, P08686 | 1.14.99.10 | Converts progesterone and 17α-hydroxyprogesterone to deoxycortisone and 11-deoxycortisol, respectively |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.