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. 2013 Dec 17;170(8):1797–1867. doi: 10.1111/bph.12451
Nomenclature 4-aminobutyrate aminotransferase (GABA transaminase)
Common abbreviation GABA-T
HGNC, UniProt ABAT, P80404
EC number 2.6.1.19: GABA + α-ketoglutaric acid = L-glutamic acid + 4-oxobutanoate, 2.6.1.22: (S)-3-amino-2-methylpropanoate + α-ketoglutaric acid = 2-methyl-3-oxopropanoate + L-glutamic acid
Cofactors pyridoxal phosphate
Selective inhibitors (pIC50) vigabatrin 214
Comment vigabatrin is an irreversible inhibitor of GABA-T 214