Nomenclature | 4-aminobutyrate aminotransferase (GABA transaminase) |
Common abbreviation | GABA-T |
HGNC, UniProt | ABAT, P80404 |
EC number | 2.6.1.19: GABA + α-ketoglutaric acid = L-glutamic acid + 4-oxobutanoate, 2.6.1.22: (S)-3-amino-2-methylpropanoate + α-ketoglutaric acid = 2-methyl-3-oxopropanoate + L-glutamic acid |
Cofactors | pyridoxal phosphate |
Selective inhibitors (pIC50) | vigabatrin 214 |
Comment | vigabatrin is an irreversible inhibitor of GABA-T 214 |