Figure 8.

Structures of the PAI subdomain of SB transposase and the DNA-bound N-terminal specific DNA-binding subdomains of Tc3 transposase (PDB codes 1tc3 and 1u78, Refs.³⁰ and³¹), Mos1 transposase (PDB code 3hos, Ref.32), and Pax5 transcription factor (PDB code 1k78, Ref.33). Protein structures were superimposed and then merely shifted along x (horizontal) axis. Residues on the second and third alpha-helices of SB PAI subdomain affected by DNA-binding are shown in black. Truncated DNA sequences from the PDB structures are shown in black to highlight the DNA-binding site of Mos1, Tc3, and Pax5 proteins.