Table 4.
Univariate analysis of factors associated with at least one positive margin for each of the margins at each width from 0 mm to 2.0 mm. Three non-pathological factors were significantly associated with a positive margin: male sex; portal vein–superior mesenteric vein resection (PV-SMVR), and neoadjuvant treatment. Values in bold refer to factors that reached significance at a P-value of <0.05; values in italics refer to factors that did not reach significance at a P-value of <0.05, but tended towards significance at a P-value of <0.10
| Margin widths, mm | ||||||
|---|---|---|---|---|---|---|
| 0 | 0.5 | 1.0 | 1.5 | 2.0 | ||
| Margins | Variables | P-value Odds ratio (95% confidence interval) | ||||
| At least one positive inked margin | Tumour size | 0.018 3.5 (1.2–9.7) | – | 0.005 2.8 (1.4–6) | 0.005 3 (1.4–6.3) | 0.051 2.2 (1–5) |
| T stage | 0.029 9.7 (1.2–74) | – | 0.003 4 (1.6–10) | 0.018 2.94 (1.2–7) | 0.007 3.6 (1.4–9) | |
| N stage | 0.018 4.5 (1.3–16) | 0.009 3.2 (1.3–7.7) | 0.004 3.2 (1.4–7) | 0.005 3 (1.4–7) | – | |
| LNR>0.2 | – | 0.017 2.5 (1.2–5.2) | 0.040 2.4 (1–5.6) | – | – | |
| PV-SMVR | <0.001 5 (2.2–12) | 0.012 2.7 (1.2–6) | – | – | – | |
| Posterior margin | N-stage | – | – | 0.012 3.45 (1.3–9) | 0.043 2.49 (1–6) | 0.035 2.42 (1–5.5) |
| LNR >0.2 | 0.075 3.1 (0.9–11) | 0.029 2.5 (1.1–5.6) | 0.005 2.9 (1.4–6) | 0.015 2.5 (1.2–5.2) | 0.022 2.4 (1.1–5) | |
| PV-SMVR | 0.007 6.0 (1.7–22) | – | – | – | – | |
| Neoadjuvant treatment | – | – | 0.045 0.4 (0.1–1) | – | 0.077 0.464 (0.2–1.1) | |
| PV-SMVm | Tumour size | 0.053 3.1 (1.0–9.6) | – | 0.001 3.7 (1.6–8.4) | 0.001 3.9 (1.7–8.8) | 0.002 3.2 (1.5–6.7) |
| T-stage | – | 0.049 4.5 (1.0–20) | 0.007 4.8 (1.5–15) | 0.016 3.6 (1.3–10) | – | |
| N-stage | – | 0.042 3.2 (1.0–9.8) | 0.032 2.5 (1.1–5.9) | 0.026 2.6 (1.1–6) | – | |
| PV-SMVR | <0.001 5.6 (2.3–14) | 0.011 2.9 (1.3–6.5) | 0.012 2.7 (1.2–5.8) | 0.016 2.6 (1.2–5.6) | – | |
| SMAm | Tumour size | – | – | 0.023 3.0 (1.16–8.06) | 0.009 3.6 (1.4–9.3) | <0.001 5.4 (2.2–13) |
| N-stage | – | – | – | 0.038 2.99 (1.06–8.39) | – | |
| LNR >0.2 | 0.010 4.3 (1.4–13) | 0.014 3.6 (1.3–9.9) | 0.004 3.2 (1.4–7) | 0.013 2.7 (1.2–5.8) | – | |
| Grade 3 | 0.050 3.6 (0.8–16) | 0.002 4.39 (1–19) | 0.014 4.83 (1.5–16) | 0.008 5.7 (1.74–18.8) | 0.002 8.00 (2.44–26.2) | |
| PV-SMVR | 0.002 5.8 (1.9–18) | 0.011 3.8 (1.4–11) | – | – | – | |
| Male versus female | – | 0.024 0.2 (0.04–0.8) | 0.054 0.4 (0.2–1.0) | – | – | |
| Vascular margin PV-SMVm + SMAm | Tumour size | 0.009 4.4 (1.4–14) | 0.027 2.7 (1.1–6.4) | <0.001 4.47 (2.0–9.8) | <0.001 4.7 (2.1–10) | <0.001 4.2 (1.9–8.9) |
| T-stage | 0.033 9.2 (1.2–71) | 0.042 3.7 (1.0–13) | 0.002 5.3 (1.8–15) | 0.005 4.2 (1.5–11) | 0.009 3.4 (1.3–8.4) | |
| N-stage | 0.022 4.3 (1.2–15) | 0.018 3.4 (1.2–9.6) | 0.011 2.9 (1.3–6.6) | 0.001 3.0 (1.3–6.8) | 0.043 2.2 (1.0–4.9) | |
| LNR >0.2 | 0.016 2.56 (1.2–5.5) | 0.015 2.6 (1.2–5.6) | 0.020 2.5 (1.1–5.3) | 0.043 2.4 (1.0–5.4) | ||
| Grade 3 | 0.049 4.0 (1.3–12) | 0.067 3.6 (1.1–11) | ||||
| PV-SMVR | <0.001 5.5 (2.4–13) | 0.006 3.0 (1.4–6.6) | 0.018 2.6 (1.2–6) | 0.023 2.5 (1.1–5.7) | 0.028 2.7 (1.1–6.4) | |
| Male versus female | – | – | 0.022 0.45 (0.22–0.88) | 0.037 0.48 (0.24–0.95) | – | |
LNR, lymph node ratio; PV-SMVm, portal vein–superior mesenteric vein margin; SMAm, superior mesenteric artery margin (uncinate margin).