Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Aug 27;2(6):751–762. doi: 10.1002/cam4.115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

PMC Copyright notice

Slug promotes chemoresistance and aggressiveness. (A) Slug or Klf4 were overexpressed in ovarian cancer stem cell (OCSC1) and spheroid formation was quantified by manual counting. (B) Cells overexpressing Slug generated a more aggressive tumor in nude mice which did not respond to Paclitaxel. Images are representative of three independent experiments (n = 10 animals per group). (C) Tumor kinetics comparing vehicle-treated or Paclitaxel-treated mice harboring tumors established from OCSC1 transfected with empty vector or overexpressing Slug (Slug). day 0 designated as beginning of treatment; day 12 is the fourth and final dose of Paclitaxel. *P < 0.05 compared to Control. **, *P < 0.001 compared to control no treatment (n = 10 animals per group).

Inline graphic — Slug promotes chemoresistance and aggressiveness. (A) Slug or Klf4 were overexpressed in ovarian cancer stem cell (OCSC1) and spheroid formation was quantified by manual counting. (B) Cells overexpressing Slug generated a more aggressive tumor in nude mice which did not respond to Paclitaxel. Images are representative of three independent experiments (n = 10 animals per group). (C) Tumor kinetics comparing vehicle-treated or Paclitaxel-treated mice harboring tumors established from OCSC1 transfected with empty vector or overexpressing Slug (Slug). day 0 designated as beginning of treatment; day 12 is the fourth and final dose of Paclitaxel. *P < 0.05 compared to Control. **, *P < 0.001 compared to control no treatment (n = 10 animals per group).