Table 1.
Description of the study population by case–control status and primary tumor site.
| Controls (n=1193) | HNSCC (n=951) | Pdifference | HNSCC by site | Pdifference | |||
|---|---|---|---|---|---|---|---|
| Oral cavity (n=355) | Pharynx (n=437) | Larynx (n=159) | |||||
| Age, mean years (σ) | 60.9 (11.0) | 59.6 (11.3) | 0.011 | 59.9 (12.7) | 58.7 (10.4) | 61.3 (10.3) | 0.042 |
| Sex, n (%) | |||||||
| Male | 868 (72.8) | 703 (73.9) | 0.563 | 228 (64.2) | 255 (81.2) | 120 (75.5) | <0.0014 |
| Female | 325 (27.2) | 248 (26.1) | 127 (35.8) | 82 (18.8) | 39 (24.5) | ||
| Race, n (%) | |||||||
| White | 1074 (90.1) | 869 (91.5) | 0.303 | 323 (91.0) | 403 (92.4) | 143 (89.9) | 0.564 |
| Non-White | 118 (9.9) | 81 (8.5) | 32 (9.0) | 33 (7.6) | 16 (10.1) | ||
| Cigarette smoking | |||||||
| Never smoker, n (%) | 480 (40.2) | 235 (24.7) | <0.0013 | 97 (27.3) | 118 (27.0) | 20 (12.6) | <0.0014 |
| Ever smoker, n (%) | 713 (59.8) | 716 (75.3) | 258 (72.7) | 319 (73.0) | 139 (87.4) | ||
| Pack-years, median (range) | 25 (0.1–200) | 34 (0.1–203) | <0.0015 | 35 (0.1–147) | 31 (0.4–203) | 41 (0.2–150) | 0.0016 |
| Alcohol consumption, n (%) | |||||||
| Nondrinker | 149 (12.5) | 88 (9.3) | <0.0013 | 36 (10.2) | 34 (7.8) | 18 (11.3) | 0.014 |
| ≤2 drinks per day | 753 (63.3) | 430 (45.3) | 166 (47.0) | 212 (48.5) | 52 (32.7) | ||
| >2 drinks per day | 288 (24.2) | 431 (45.4) | 151 (42.8) | 191 (43.7) | 89 (56.0) | ||
| Highest level of education, n (%) | |||||||
| High school or less | 327 (27.5) | 389 (40.9) | <0.0013 | 158 (44.5) | 151 (34.6) | 80 (50.3) | 0.0014 |
| Greater than high school | 864 (72.5) | 562 (59.1) | 197 (55.5) | 286 (65.5) | 79 (49.7) | ||
| HPV16L1 serostatus, n (%) | |||||||
| Negative | 965 (93.4) | 584 (70.5) | <0.0013 | 264 (86.8) | 206 (52.8) | 114 (84.4) | <0.0014 |
| Positive | 68 (6.6) | 245 (29.6) | 40 (13.2) | 184 (47.2) | 21 (15.6) | ||
1
Two-sample t-test for difference between cases (all HNSCC) and controls.
2
ANOVA for difference across primary tumor sites (cases only).
3
Fisher's exact test for difference between cases (all HNSCC) and controls.
4
Fisher's exact test for difference across primary tumor sites (cases only).
5
Rank-sum test for difference between cases (all HNSCC) and controls.
6
Kruskal–Wallis test for difference across primary tumor sites (cases only).