Table 3.
Head and neck squamous cell carcinoma risk from any lifetime exposure to occupational dusts and by duration at exposed occupation, overall and by primary tumor site.
| Occupational dust | HNSCC | Oral cavity | Pharyngeal | Laryngeal | ||||
|---|---|---|---|---|---|---|---|---|
| ncases/ncontrol | OR1 (95% CI) | ncases/ncontrol | OR1 (95% CI) | ncases/ncontrol | OR1 (95% CI) | ncases/ncontrol | OR1 (95% CI) | |
| Sawdust | ||||||||
| Never exposed | 708/927 | Reference | 277/927 | Reference | 327/927 | Reference | 104/927 | Reference |
| Ever exposed | 243/266 | 1.0 (0.8, 1.2) | 78/266 | 0.9 (0.6, 1.2) | 110/266 | 0.9 (0.7, 1.2) | 55/266 | 1.4 (1.0, 2.2) |
| Per decade of exposure | 224/249 | 1.0 (0.9, 1.1) | 71/249 | 0.9 (0.8, 1.0) | 99/249 | 1.1 (1.0, 1.2) | 54/249 | 1.2 (1.0, 1.3)*2 |
| Concrete dust | ||||||||
| Never exposed | 768/991 | Reference | 294/991 | Reference | 345/991 | Reference | 129/991 | Reference |
| Ever exposed | 183/202 | 0.9 (0.7, 1.2) | 61/202 | 0.9 (0.6, 1.3) | 92/202 | 1.1 (0.8, 1.5) | 30/202 | 0.9 (0.5, 1.4) |
| Per decade of exposure | 169/187 | 1.0 (0.9, 1.1) | 58/187 | 0.9 (0.8, 1.1) | 84/187 | 1.0 (0.9, 1.2) | 27/187 | 1.0 (0.9, 1.2) |
| Leather dust | ||||||||
| Never exposed | 911/1160 | Reference | 343/1160 | Reference | 417/1160 | Reference | 151/1160 | Reference |
| Ever exposed | 40/33 | 1.2 (0.7, 2.1) | 12/33 | 0.9 (0.5, 1.9) | 20/33 | 1.3 (0.7, 2.6) | 8/33 | 1.2 (0.5, 2.9) |
| Per decade of exposure | 37/26 | 1.5 (1.2, 1.9)* | 11/26 | 1.3 (0.9, 1.8) | 19/26 | 1.7 (1.2, 2.2)* | 7/26 | 1.5 (1.0, 2.2) |
| Metal dust | ||||||||
| Never exposed | 790/988 | Reference | 303/988 | Reference | 361/988 | Reference | 126/988 | Reference |
| Ever exposed | 161/205 | 0.9 (0.7, 1.1) | 52/205 | 0.8 (0.5, 1.1) | 76/205 | 0.9 (0.6, 1.3) | 33/205 | 1.1 (0.7, 1.7) |
| Per decade of exposure | 148/192 | 1.0 (0.9, 1.1) | 47/192 | 0.9 (0.8, 1.1) | 70/192 | 1.0 (0.9, 1.2) | 31/192 | 1.2 (1.0, 1.4) |
| Chimney soot | ||||||||
| Never exposed | 880/1103 | Reference | 335/1103 | Reference | 400/1103 | Reference | 145/1103 | Reference |
| Ever exposed | 71/90 | 0.9 (0.6, 1.3) | 20/90 | 0.7 (0.4, 1.2) | 37/90 | 1.2 (0.7, 1.9) | 14/90 | 1.0 (0.5, 1.9) |
| Per decade of exposure | 63/85 | 1.0 (0.9, 1.1) | 18/85 | 0.9 (0.7, 1.1) | 32/85 | 1.1 (0.9, 1.3) | 13/85 | 1.0 (0.8, 1.2) |
*
P≤0.05.
1
Adjusted for age, gender, race, smoking, alcohol consumption, education, and HPV16 exposure.
2
Actual estimated value of the lower confidence interval is 1.0004 (P=0.049).