Table 1.

T and B cell subpopulations in proteolipid protein (PLP)_139–151-immunized susceptible and resistant mouse strains

Cell population	Number of mice	Resistant strain (%)	Susceptible strain (%)
CD4+ naive T cells	13	14·2 (3·5)	20·1 (8·0)*
CD4+ activated T cells	13	2·9 (1·1)	4·8 (1·3)**
CD4+ regulatory T cells	5	29·6 (6·8)	49·9 (15·1)*
CD8+ naive T cells	13	6·1 (2·7)	7·7 (3·5)
CD8+ activated T cells	13	0·2 (0·2)	0·2 (0·1)
CD8+ regulatory T cells	5	1·3 (2·4)	4·1 (2·5)
B2 cells	13	41·1 (8·8)	49·6 (9·2)*
B1 cells	13	2·6 (1·2)	2·7 (0·8)
Regulatory B cells	13	3·5 (1·8)	3·2 (1·3)

The data are expressed as the mean values ± standard deviation. The percentages of regulatory CD4⁺ and CD8⁺ T cells refer to the frequencies of forkhead box protein 3 (FoxP3)⁺ cells within the CD4⁺CD25⁺ and CD8⁺CD25⁺ populations, respectively. The frequency of regulatory B cells refers to the percentage of CD5⁺CD1d⁺ events within the B220⁺ population. The frequencies of the remaining T and B cell subsets are in reference to the total lymphocyte population.

* P < 0·05 and **P < 0·01.