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. 2014 Jan 3;175(2):285–295. doi: 10.1111/cei.12220

Fig. 3.

Fig. 3

Argatroban (Arg) and C5aR antagonist (PMX53) inhibited C5aR expression when treated individually and together by Western blot. In the sham group, intracerebral haemorrhage (ICH) 3 days, argatroban treatment ICH 3 days, C5aRA (PMX53) treatment and combination treatment groups, the optical density (OD) values were 0·19 ± 0·03, 0·76 ± 0·02, 0·59 ± 0·027, 0·41 ± 0·025 and 0·22 ± 0·02, respectively. The expression of C5aR in the ICH 3 days group reached the maximum level, significantly differently from other groups (P < 0·05, n = 5, versus sham, ICH 3 days + Arg, ICH 3 days + C5aRA groups and combination treatment groups), and in the combination group reached a lower level compared with 3 days ICH, 3 days ICH + Arg and 3 days ICH + C5aRA groups (P < 0·05, n = 5, versus ICH 3 days, 3 days ICH + Arg and 3 days ICH + C5aRA groups).