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. 1971 Jul;68(7):1623–1626. doi: 10.1073/pnas.68.7.1623

Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium

Michael M Hart 1, Richard H Adamson 1,*
PMCID: PMC389254  PMID: 5283954

Abstract

The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)50 as a measure, the decreasing order of toxicity was TlCl3 ≥ In(NO3)3 > Ga(NO3)3 > Al(NO3)3. All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga+3 and, to a lesser extent, In+3 inhibited tumor growth. Ga(NO3)3 was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.

Keywords: Walker 256 carcinosarcoma, reticulum cell sarcoma, lymphosarcoma, mammary carcinoma, leukemia

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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