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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2013 Sep 4;6(5):960–966. doi: 10.1161/CIRCEP.113.000439

Figure 1.

Figure 1

S140G-IKs and HET-IKs exhibit enhanced sensitivity to HMR-1556. A, B and C, Representative current recordings from cells expressing WT-IKs (A), S140G-IKs (B), or HET-IKs (C). Recordings illustrated in A, B and C were obtained using the activation protocol described in the Methods. D, E, and F, Average current densities (current normalized to cell capacitance) elicited by a 2 s voltage step to +40 mV followed by a 10 s interpulse during application of vehicle or various concentration of HMR-1556 from cells expressing WT-IKs (D), S140G-IKs (E), or HET-IKs (F). Current density traces in D, E, and F are averages from 9–11 cells.