Table 4. Simulation of positive and negative predictive values of Ziehl-Neelsen staining, culture, and polymerase chain reaction dot-blot assays, according to different tuberculosis prevalence rates.
Simulated prevalence rates | Subjects with HIV N=74 |
Subjects without HIV N=203 |
||
---|---|---|---|---|
TB N=40 |
TB N=34 |
TB N=88 |
TB N=115 |
|
PPV | NPV | PPV | NPV | |
5% | ||||
ZN / cuture | 100 | 99 | 83 | 100 |
ZN / PCR dot-blot | 23 | 99 | 23 | 100 |
PPV | NPV | PPV | NPV | |
10% | ||||
ZN / cuture | 100 | 99 | 91 | 99 |
ZN / PCR dot-blot | 38 | 98 | 39 | 99 |
PPV | NPV | PPV | NPV | |
20% | ||||
ZN / cuture | 100 | 97 | 96 | 99 |
ZN / PCR dot-blot | 58 | 98 | 59 | 98 |
PPV | NPV | PPV | NPV | |
30% | ||||
ZN / cuture | 100 | 95 | 98 | 98 |
ZN / PCR dot-blot | 71 | 93 | 71 | 96 |
PPV | NPV | PPV | NPV | |
40% | ||||
ZN / cuture | 100 | 93 | 98 | 97 |
ZN / PCR dot-blot | 79 | 89 | 79 | 94 |
PPV | NPV | PPV | NPV | |
46%* | ||||
ZN / cuture | 99 | 88 | 98 | 96 |
ZN / PCR dot-blot | 87 | 82 | 83 | 93 |
PPV, positive predictive value; NPV, negative predictive value.
the present study.