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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: J Reprod Dev. 2012;58(3):283–287. doi: 10.1262/jrd.2011-039

Fig. I.

Fig. I

Hypoxia signaling and activation of the invasive trophoblast cell lineage and trophoblast cell-directed uterine spiral artery remodeling. Panel A} Effects of maternal hypoxia on placentation. Exposure to maternal hypoxia increases uterine vascularity, endovascular invasive trophoblast cell invasion, and cellular allocation to the junctional zone of the chorioallantoic placenta. Panel B) Schematic representation of the effects of oxygen tension on TS cells and HIF-dependent trophoblast cell 1ineage decisions.