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. 2013 Aug 15;94(1):139–150. doi: 10.2522/ptj.20130027

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Figure 2. — Interhemispheric intervention (IHI): participant with stroke. (A) Magnetic resonance images of brain of participant with stroke (red arrows). (B) Mean (SD) values showing exaggerated IHI in direction of contralesional primary motor area (M1) inhibiting ipsilesional primary motor areas (M1) (contralesional to ipsilesional), derived from multiple trials of C–D, compared with direction of ipsilesional M1 inhibiting contralesional M1 (ipsilesional to contralesional), derived from multiple trials of E–F. (C) Motor-evoked potential (MEP) in paretic first dorsal interosseous muscle (FDI) (upper trace) in response to unconditioned suprathreshold test stimulus applied to the ipsilesional M1. (D) Motor-evoked potential in nonparetic FDI (lower trace) in response to suprathreshold conditioning stimulus applied to the contralesional M1, followed by an MEP in paretic FDI in response to test stimulus applied to the ipsilesional M1 (interstimulus interval=10 ms). Interhemispheric intervention in the direction of the contralesional M1 inhibiting the ipsilesional M1 is demonstrated by reduction in conditioned test MEP (lower red circle) compared with unconditioned test MEP (upper red circle). (E–F) Interhemispheric intervention in the direction of ipsilesional to contralesional M1 (compare yellow circles).