Figure 3.

Metaplastic effects as predicted by Bienenstock-Cooper-Munro theory. (Top) Motor-evoked potentials (MEPs) from one participant's abductor pollicis brevis muscle collected for 10 minutes before (Pre) and up to 60 min (six 10-min bins) following delivery of sham 6-Hz priming stimulation + 1-Hz low-frequency repetitive transcranial magnetic stimulation (rTMS). (Bottom) Similar MEP collection taken from the same participant before and after active 6-Hz priming + 1-Hz low-frequency rTMS. Preceding low-frequency stimulation with active high-frequency priming resulted in an enhancement of corticospinal depression, as depicted by reduced MEP amplitude for a longer duration versus sham priming. Figure used with permission.⁵⁰