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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2013 May 24;21(15):4678–4686. doi: 10.1016/j.bmc.2013.05.018

Table 1.

EC50 values of selected cembranoids.

Analogue Maximum recovery Minimum recovery Hill-slope EC50 nM QSAR
1 83±3 30±6 3.2±1.4 63±9 4.78
2 55±7 32±5 n/a n/a 1.74
6 88±8 45±4 2.5±1.6 277±87 3.23
7 70±1 30±2 1.6±0.3 14±2 2.41
10 76±2 36±7 1.6±0.9 87±36 4.22
15 85±7 37±2 24.0±10.2 31±1 4.39

Columns 2-5 indicate the parameters for the best fit to the logistic equation f=min + (max-min)/(1+(x/EC50)^ (-Hillslope)), which was used to fit the concentration-protection curves of cembranoids in column 1 (also see Figures 7A-7F). All regression coefficients were > 0.9. The QSAR number is defined in Table 2.