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. 2014 Jan 15;4:3701. doi: 10.1038/srep03701

Figure 7. CS controls the functional integrity of ESCs by binding to E-cadherin.

Figure 7

In GlcAT-I−/− ESCs, homophilically interacting E-cadherin inhibits the differentiation of ESCs due to the disruption of the binding of CS to E-cadherin. On the other hand, in Wt ESCs, the interaction between CS and E-cadherin stimulates the tendency of ESCs to differentiate by counterbalancing signaling pathways and transcription factors that promote native pluripotency.