Table 3 . Biochemical and inflammatory parameters of the rat colon 6 days after induction of colitis with TNBS (50 mg/kg).
| Group | MPO activity
(Unit/100 mg wet tissue) |
TNF-α
(pg/g wet tissue) |
IL-6
(pg/g wet tissue) |
IL-1β
(pg/g wet tissue) |
| Normal | 0.6 ± 0.1 | 141.0 ± 13.8 | 3663.3 ± 240.2 | 1647.5 ± 452.4 |
| TNBS-control | 3.4 ± 0.4 | 249.9 ± 26.6 | 5210.3 ± 457.9 | 15296.0 ± 1579.7 |
| Trop. (2mg/kg, i.p.) | 1.9 ± 0.2 * | 163.7 ± 8.6 * | 3800.5 ± 164.8 * | 8770.8 ±1047.3 ** |
| mCPBG (5mg/kg, i.p.) | 3.5 ± 0.3 | 250.0 ± 23.1 | 5152.0 ± 385.3 | 15317.9 ± 1315.7 |
| mCPBG+ Trop. | 3.4 ± 0.3 | 251.8 ±18.5 | 5249.0 ± 312.5 | 15580.9 ± 1486.3 |
| Dex. (1mg/kg, i.p.) | 1.9 ± 0.4 * | 160.6 ± 12.6 * | 3821.7 ± 270.7 * | 8641.2 ± 985.2 ** |
1 TNBS,2,4,6-trinitrobenzenesulfonic acid; Trop., tropisetron; mCPG, meta-chlorophenylbiguanide; Dex., dexamethasone; i.p., intraperitoneal.
2 Values are means ± SEM; n =6.
3**P < 0.01 and *P < 0 .05: Significant difference compared to TNBS-control group.