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. 2013 Nov 12;4(6):e00729-13. doi: 10.1128/mBio.00729-13

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Copyright © 2013 Nelson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 2 — Structure of retro-2^cycl and inhibitory activities of retro-2 analogs. (A) The structure of retro-2^cycl was solved by X-ray diffraction, and it was verified to be a DHQ. (B) Retro-2^cycl protects cells from polyomavirus infection. Cells were pretreated with retro-2, the indicated analog, the vehicle control, or BFA (71 nM, 20 ng/ml) and infected with JCPyV. Infected cells were scored and normalized to the vehicle-treated control. The data represent the average of triplicate samples. Error bars indicate the standard deviation.