Multivariate analysis of TLG and overall survival in bone metastases

Variable	P-value	Hazard ratio
TLG	0.021
Lower tertile		Reference
Middle tertile		1.09 (0.58–2.04)
Upper tertile		2.19 (1.17–4.07)
ER/PR and HER2	<0.011
ER or PR+, HER2−		Reference
HER2+		0.89 (0.47–1.70)
Triple-negative		2.65 (1.43–4.92)
Grade (Grade 2 vs. 3)	0.08	1.73 (0.93–3.22)
Histology	0.44
Ductal		Reference
Lobular		0.57 (0.17–1.88)
Other		1.43 (0.59–3.46)
Visceral metastases (+ vs. −)	<0.011	2.14 (1.27–3.58)

Hazard ratios (HR) are reported as estimate (95% confidence interval). TLG, total lesion glycolysis; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.

Indicates statistically significant values.