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. 2013 Sep 17;2(5):734–743. doi: 10.1002/cam4.118

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© 2013 Published by John Wiley & Sons Ltd.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Thiocoraline functionally activates the Notch pathway. Real-time RT-PCR demonstrated activation of downstream targets of Notch pathway, HES1 (A), HES2 (B), HES6 (C), and HEY1 (D) in TT cells. While HES1 and HES2 transcript levels significantly increased with thiocoraline treatment comparing to the control (all values are expressed as mean ± SD with *P < 0.05 and **P < 0.01), decreasing values of HES6 and increasing values of HEY1 expression failed to reach statistical significance in comparison to the control. Western blot demonstrated an increase in HEY2 (E) at the protein level in TT cells.