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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Dev Cell. 2012 Aug 16;23(3):637–651. doi: 10.1016/j.devcel.2012.07.008

Figure 1. Transient activation of canonical Wnt signaling induces nephron progenitors to undergo a mesenchymal-to-epithelial transition.

Figure 1

(A) Aggregated Six2-GFP+ nephron progenitors were incubated for 24 hrs with either BIO or DMSO (vehicle) and further incubated for an additional 24 hrs with either BIO or DMSO. (B) Transcriptional profiles of nephron progenitors after activation of canonical Wnt signaling under dispersed or aggregated culture conditions. Aggregated nephron progenitors were exposed to either transient activation (B➔D, 24 hrs with BIO followed by another 24 hrs without BIO) or constitutive activation of canonical Wnt signaling (B➔B, 24 hrs with BIO and another 24 hrs with BIO).