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In undifferentiated nephron progenitors (Cited1+ cells), Six2/Lef/Tcf complexes prevents β-catenin from activating class I genes, such as Fgf8 and Wnt4. In differentiating nephron progenitor cells, a high dosage of Wnt9b activates class I genes by elevating β-catenin level and lowering Six2 level.
