Table 2.

Onset of Charles Darwin’s clinical manifestations, including those suggestive of mitochondrial disorder

Symptom	Onset	Typical MID feature	Reference
Clear onset
Dyslexia	Boyhood	Yes	51
Scarlet fever	9 years	No	47
Flatulence	Boyhood	Yes	58,65
Painful lips, eczema	19 years	No	65,81,82
Periodic nausea, vomiting	20 years	Yes	55,60,65,69
Fatigue, lethargy	20 years	Yes	43
Abnormal seasickness	22 years	Yes	58
Palpitations	22 years	Yes	58,83,84
Faintness, sinking feeling	23 years	Yes
Exercise intolerance	23 years	Yes	58
Headache	23 years	Yes	55,85–87
Panic attacks, fear	29 years	No	58
Overtiredness	30 years	Yes	88,89
Exhaustion	30 years	Yes	90
Eructation, belching	31 years	Yes	91
Muscle weakness	33 years	Yes	58
Fatigue	43 years	Yes	53,55,64
Prostration	49 years	Yes	92
Loss of memory	54 years	Yes	67
Myalgia	55 years	Yes	93
Atrial fibrillation	63 years	Yes	51
Unclear onset
Finger numbness	Uk	Yes	57,66
Dental problems	Uk	No	51
Tan skin (hyperpigmentation)	Uk	No	51
Transient weakness	Uk	Yes	51
Bloating, abdominal pain	Uk	No	51
Dizziness, whizzing, swimming head	Uk	Yes	51
Muscle twitching	Uk	Yes	51
Sweating, temperature sensitivity	Uk	Yes	51
Muscle weakness	Uk	Yes	51
Visual disturbances	Uk	Yes	51
Edema of face, arm, knee, leg	Uk	Yes	51
Lumbago	Uk	No	51
Speech arrest	Uk	Yes	51
Depression	Uk	Yes	51
Tight chest, dyspnea	Uk	Yes	51
Recurrent boils	Uk	No	51
Hematemesis	Uk	No	51
Chest pain, death April 19, 1882 from myocardial infarction	73 years

Abbreviations: MID, mitochondrial disorder; Uk, unknown.